About the divide between classical mechanics and quantum mechanics, in the field of particle physics there has been many advances on the topic:
The idea that there is a divide, the so called classical limit is a fallacy since it only apply for binary theories.
It is perfectly possible to create hybrid classical hybrid quantum mechanics: semiclassical mechanics.
The most successful semiclassical theory is Stochastic electrodynamics:
https://en.wikipedia.org/wiki/Stochastic_electrodynamics and it has been shown in papers to eliminate the classical limit, moreover it has many merits over QM, such as better explaining the zero point field energy, the casimir effect, the trajectories, paradoxes, etc.
Moreover stochastic electrodynamics is both easier and order of magnitudes more efficient to compute than quantum mechanics so it scales to large systems.
Since those knowledge are very little known, I expect nobody on earth has tried to apply them to molecular mechanics or to an improved variant.
But stochastic electrodynamics could improve the accurary at scales that cannot be computed in QM.
also specifically for long range interactions I suppose studying Rydberg atoms could be insightful since they have the longest electronic distances possible
Hi Abhi, thanks for creating a high signal podcast, as as student of ML in drug discovery I found myself taking notes and looking up things every now and then. Nice production!
This interview has unusually OOD-high ROI in a discipline notorious for extremely low ROIs.
Maybe this is finally on the cusp of changing soon (with NNPs and modeling of noncanonical amino acids)
About the divide between classical mechanics and quantum mechanics, in the field of particle physics there has been many advances on the topic:
The idea that there is a divide, the so called classical limit is a fallacy since it only apply for binary theories.
It is perfectly possible to create hybrid classical hybrid quantum mechanics: semiclassical mechanics.
The most successful semiclassical theory is Stochastic electrodynamics:
https://en.wikipedia.org/wiki/Stochastic_electrodynamics and it has been shown in papers to eliminate the classical limit, moreover it has many merits over QM, such as better explaining the zero point field energy, the casimir effect, the trajectories, paradoxes, etc.
Moreover stochastic electrodynamics is both easier and order of magnitudes more efficient to compute than quantum mechanics so it scales to large systems.
https://arxiv.org/abs/1903.00996
There are many semiclassical alternatives to QM outlined here
https://www.researchgate.net/publication/374257062_The_zitterbewegung_electron_puzzle
such as the holographic principle.
Since those knowledge are very little known, I expect nobody on earth has tried to apply them to molecular mechanics or to an improved variant.
But stochastic electrodynamics could improve the accurary at scales that cannot be computed in QM.
also specifically for long range interactions I suppose studying Rydberg atoms could be insightful since they have the longest electronic distances possible
Love it!
Hi Abhi, thanks for creating a high signal podcast, as as student of ML in drug discovery I found myself taking notes and looking up things every now and then. Nice production!
AMAZING!!! 🤯🤯🤯
Brilliant first show, well done to the host and the guests!
Love how you went down the boiling water rabbit hole. A gem. Such a great interview!
Great podcast, and very well-produced, especially for a first go.
congrats on the podcast! looking forward to listening!